Protein Modification Reagents
Medchemexpress LLC Boc-NH-PEG4-CH2COOH | 876345-13-0 | MFCD30528568 | ≥97.0% | 351.39 g/mol | C15H29NO8 | 5 G
Boc-NH-PEG4-CH2COOH is a Boc-protected polyethylene glycol (PEG4) linker with a terminal carboxylic acid group used as a building block in bioconjugation chemistry, including PROTACs, antibody-drug conjugates, and peptide coupling.
- Boc-protected primary amine enabling orthogonal deprotection
- PEG4 spacer provides solubility and flexibility
- Terminal carboxylic acid suitable for amide coupling
- Molecular weight 351.39 g/mol
- High purity ≥97.0%
- CAS number 876345-13-0 for unambiguous identification
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 100 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It leverages the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Peg-based protac linker
- Utilized in the synthesis of protacs
- Consists of two distinct ligands connected by a linker
- Targets E3 ubiquitin ligase and protein of interest
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Propargyl-PEG4-Tos | 875770-32-4 | 99.3% | 500 MG
Propargyl-PEG4-Tos is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a cleavable ADC linker for synthesizing antibody-drug conjugates (ADCs) and serves as a click chemistry reagent containing an Alkyne group. This allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Cleavable ADC linker
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-PNP | 2112738-09-5 | MFCD30828694 | 96.2% | 871.89 | C40H53N7O15 | 100 MG
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimide reactive group for thiol conjugation, a PEG4 spacer, the Val-Cit protease-cleavable dipeptide, a PAB self-immolative spacer, and a PNP leaving group. Intended use is research on ADC linker and payload conjugation.
- Cleavable four-unit PEG linker suitable for ADC chemistry.
- Maleimide reactive group for thiol conjugation.
- Val-Cit dipeptide provides protease-cleavable release.
- PAB self-immolative spacer enables payload release after cleavage.
- PNP terminal group provides an activated ester for coupling.
- Available in multiple package sizes for research use.
Medchemexpress LLC MAK683-CH2CH2COOH hydrochloride | 00-00-0 | 99.6% | 484.91 g·mol⁻¹ | C23H22ClFN6O3 | 5 MG
MAK683-CH2CH2COOH hydrochloride is a PROTAC linker supplied as a high-purity solid for research use. It binds to the EED protein and has been used with an E3 ligase ligand to design PROTAC degraders. Handle and store under recommended conditions to preserve stability and activity.
- Binds to EED (embryonic ectoderm development protein).
- High purity: 99.6%.
- Molecular weight: 484.91 g·mol⁻¹.
- Physical form: solid, white to light yellow.
- Storage: keep refrigerated at 4°C and protect from light; store under inert gas for long-term stability.
- Available in small milligram packages for research workflows.
Medchemexpress LLC m-PEG4-CH2COOH | 16024-66-1 | 99.9% | 5 G
m-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Molecular weight: 266.29
- Formula: C11H22O7
- Appearance: Liquid (density: 1.125 g/cm³)
- Color: Colorless to light yellow
- Shipping at room temperature (in continental US)
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- In vitro solubility: DMSO: 100 mg/mL
- In vivo solubility: ≥ 2.5 mg/mL in various protocols